PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. Synonyms: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5,6:4,5]thieno[3,2-f]quinolin-8-one CAS No: 1276121-88-0 Molecular Formula: C21H18N4OS Molecular Weight: 374.46 Purity (HPLC): 98% Appearance: White to yellow solid Melting Point: >180C (dec.) (lit) Solubility: DMSO to 40nM Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis TLC Conditions: Rf=0.41 (5% 7M methanolic ammonia/DCM) Elemental Analysis: Calculated: %C: 66.56, %H: 4.92, %N: 14.78 Storage and Stability: Long-term storage is recommended at 4C. Stable for 6 months after receipt.
Molekulargewicht:
378.96
CAS Nummer:
[1276121-88-0]
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