| T-2 toxin is a common trichothecene mycotoxin produced by Fusarium species, which can infect grain crops causing alimentary toxic aleukia in humans and animals. It triggers a ribotoxic response through its high binding affinity to peptidyl transferase, which is an integral part of the 60S ribosomal subunit, resulting in activation of JNK/p38 MAPKs, interferes with the metabolism of membrane phospholipids, and increases liver lipid peroxides.1 T-2 toxin is highly cytotoxic to macrophages, inducing apoptosis in primary porcine alveolar macrophage cells with an IC50 value of 19.47 nM. At 3 nM it decreases the production of inflammatory mediators (IL-1beta, TNFalpha, and nitric oxide), TLR4, and TLR2/6 agonists.2 Alternate Names: (3alpha,4beta,8alpha)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-Diacetate 8-(3-Methylbutanoate), 12,13-Epoxytrichothec-9-ene-3alpha,4beta,8alpha,15-tetrol 4,15-Diacetate 8-Isovalerate, 4beta,15-Diacetoxy-8alpha-(3-methylbutyryloxy)- 12,13-epoxytrichothec-9-en-3alpha-ol, 8alpha-(3-Methylbutyryloxy)-4beta,15- diacetoxyscirp-9-en-3alpha-ol, Fusariotoxin T 2, Insariotoxin, Mycotoxin T 2, NSC 138780, T 2, T 2 mycotoxin, T-2 Lienomycin, Toxin T 2 CAS Number: 21259-20-1 Appearance: White Solid Purity: 98% Melting Point: 140-143C Storage: -20°C Freezer Solubility: Cyclohexane (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly) |
