| D-Tetrahydropalmatine is an alkaloid isolated from a traditional Chinese herb Rhizoma Corydalis (yanhusuo). D-Tetrahydropalmatine inhibits dopamine and serotonin uptake of synaptosomes in the rat brain. D-Tetrahydropalmatine also shows inhibitory effects on acetylcholinesterase and butyrylcholinesterase. Synonyms: (13aR)-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine, 2,3,9,10-Tetramethoxy-13abeta-berbine, (+)-(R)-Tetrahydropalmatine, (+)-2,3,9,10-Tetramethoxyberbine, (+)-Corydalis B, (R)-Tetrahydropalmatine, (+)-Tetrahydropalmatine Alkaloid, Corydalis B, d-Tetrahydropalmatine CAS No: 3520-14-7 Molecular Formula: C21H25NO4 Molecular Weight: 355.43 Purity (HPLC): 97% Appearance: White to pale yellow solid Melting Point: 142-145C (lit) Solubility: Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis TLC Conditions: SiO2: Dichloromethane: Methanol: NH4OH, 9:1:0.1: Visualized with UV, AMCS, KMnO4, and Ninhydrin, Single spot, Rf=0.75 Elemental Analysis: Calculated: %C: 70.96, %H: 7.09, %N: 3.94 Specific Rotation (c=0.1, Ethanol): As Reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
