Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete's foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies. Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin. Synonyms: N-Methyl-N-(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester, Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester, 2-Naphthyl N-Methyl-N-(3-tolyl)thiocarbamate, Aftate, Chinofungin, Dermoxin, Phytoderm, Pitrex, Sch 10144, Tolnaphthate, Tolsanil, Tonoftal, Tritin CAS No: 2398-96-1 Molecular Formula: C19H17NOS Molecular Weight: 307.41 Appearance: White to off-white solid Purity: 98% Melting Point: 109-112C Solubility: Chloroform (Slightly), DMSO (Slightly) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
307.41
Reinheit:
98%
Formulierung:
White to off-white solid
CAS Nummer:
[2398-96-1]
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