A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50~50uM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50-100uM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC50=50 mM and 64mM, respectively). Synonyms: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4- pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride CAS No: 1177865-17-6 Molecular Formula: C24H38Cl3N7 Molecular Weight: 530.96 Appearance: Supplied as a lyophilized powder. Purity: ~99% (HPLC) Solubility: Soluble to 100mM in water and to 100mM in DMSO. TLC Conditions: Rf = 0.39 (Pyridine: Acetic acid: Water: Butanol [3:8:11:22]) Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis Elemental Analysis: Calculated: %C: 51.66, %H: 7.41, %N: 17.57 Storage and Stability: Stored at RT. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
530.96
Reinheit:
!~99% (HPLC)
Formulierung:
Supplied as a lyophilized powder.
CAS Nummer:
[1177865-17-6]
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