ERI1, NT (ERI1, 3EXO, THEX1, 3-5 exoribonuclease 1, 3-5 exonuclease ERI1, Eri-1 homolog, Histone mRNA 3-end-specific exoribonuclease, Histone mRNA 3-exonuclease 1, Protein 3hExo), Rabbit
Artikelnummer:
USB-035206
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| Artikelname: | ERI1, NT (ERI1, 3EXO, THEX1, 3-5 exoribonuclease 1, 3-5 exonuclease ERI1, Eri-1 homolog, Histone mRNA 3-end-specific exoribonuclease, Histone mRNA 3-exonuclease 1, Protein 3hExo), Rabbit |
| Artikelnummer: | USB-035206 |
| Hersteller Artikelnummer: | 035206 |
| Alternativnummer: | USB-035206-200 |
| Hersteller: | US Biological |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, WB |
| Immunogen: | ERI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-109 amino acids from the N-terminal region of human ERI1. |
| RNA exonuclease that binds to the 3-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 and 3-hydroxyl groups at the last nucleotide of the histone 3-end is required for efficient degradation of RNA substrates. Also able to degrade the 3-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5-ACCCA-3 sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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