GAD1, CT (GAD1, GAD, GAD67, Glutamate decarboxylase 1, 67kD glutamic acid decarboxylase, Glutamate decarboxylase 67kD isoform), Rabbit

Produktübersicht

• Artikelname: GAD1, CT (GAD1, GAD, GAD67, Glutamate decarboxylase 1, 67kD glutamic acid decarboxylase, Glutamate decarboxylase 67kD isoform), Rabbit
• Artikelnummer: USB-035867
• Hersteller Artikelnummer: 035867
• Alternativnummer: USB-035867-200
• Hersteller: US Biological
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Immunogen: GAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-551 amino acids from the C-terminal region of human GAD1.

Produktbeschreibung

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Produkteigenschaften

• NCBI: 000808
• UniProt: Q99259
• Reinheit: Purified by Protein A affinity chromatography.
• Formulierung: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.