Antibiotic. Antiprotozoal. Antimicrobial. Cytotoxic and genotoxic in various mammalian cells. Mitochondrial permeability transition pore (MPTP) activator. Apoptosis inducer. ERK and JNK signaling pathways activator. Nephrotoxic mycotoxin. Suppresses NO and iNOS expression via inhibition of the JAK/STAT-1alpha and NF-kappaB signaling pathways. Tubulin polymerization and mitotic spindle assembly inhibitor. Increases reactive oxygen species (ROS). Induces cell cycle arrest at the G0/G1 and G2/M phase. Synonyms: NSC 186, BRN 0088597, Antimycin, 4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid CAS Number: 518-75-2 Source: Penicillium citrinum strain FKI-4836 Molecular Weight: 250.3 Molecular Formula: C13H14O5 Solubility: Methanol, ethanol, methylene chloride, pyridine or dioxane. Insoluble in water, chloroform or hexane. Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9). Appearance: Supplied as a yellow solid. Purity: 97% (HPLC) Storage and Stability: Store at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
250.3
Reinheit:
97% (HPLC)
Formulierung:
Supplied as a yellow solid.
CAS Nummer:
[518-75-2]
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