Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer and thrombopoietic agent. Source: Semi-synthetic from colchicine: Synonyms: Demecolcine, BRN 2822892 CAS Number: 477-30-5 Molecular Weight: 371.4 Molecular Formula: C21H25NO5 Method for Determining Identity: Proton NMR Appearance: Supplied as a white to off-white powder. Purity: 98% (HPLC) Solubility: Soluble in chloroform, ethanol, or DMSO SStorage and Stability: Store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
371.4
Reinheit:
98% (HPLC)
Formulierung:
Supplied as a white to off-white powder.
CAS Nummer:
[477-30-5]
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