Cell permeable gamma-secretase inhibitor (IC50 = 115nM for total beta-amyloid, IC50 = 200nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). Does not inhibit persenilinase. Notch processing inhibitor. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling. CDK5 activity inhibitor. Apoptosis enhancer. Synonyms: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine tert.butyl ester CAS Number: 208255-80-5 Molecular Weight: 432.5 Molecular Formula: C23H26F2N2O4 Solubility: 100% ethanol, DMSO (20mg/ml) or dichloromethane Appearance: Supplied as a white to off-white solid. Purity: 98% (NMR) Storage and Stability: Store at 4C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
432.5
Reinheit:
98% (NMR)
Formulierung:
Supplied as a white to off-white solid.
CAS Nummer:
[208255-80-5]
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