Antibiotic. Protein tyrosine kinase inhibitor. Has antifungal, antimalarial, antiangiogenic (in vivo), anti-inflammatory and antiviral activity. Cyclooxygenase-2 (COX-2) expression inhibitor without affecting COX-1 expression in LPS-stimulated macrophages. Induces the differentiation of HL-60 cells into macrophages. Potent HSP90 inhibitor. Anticancer compound. In vivo Rad/Raf interaction inhibitor. Inhibitor of AP-1-, NF-kappaB- and serum response factor (SRF)-mediated transcription. Suppresses expression of iNOS (NOS II). Non-competitive inhibitor of ATP citrate lyase. DNA topoisomerase VI and type II DNA topoisomerase inhibitor. Protects against LPS/IFN-gamma-induced neuronal cell death. Apoptosis inducer. Synonyms: Monorden, NSC 294404, RHI-12648 CAS Number: 12772-57-5 Source: Gilmaniella sp. Molecular Weight: 364.8 Molecular Formula: C18H17ClO6 Solubility: DMSO, methanol, acetone, ethyl acetate or chloroform Appearance: Supplied as a white to slightly yellow solid. Purity: 99% (HPLC) Storage and Stability: Store at 4C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
364.8
Reinheit:
99% (HPLC)
Formulierung:
Supplied as a white to slightly yellow solid.
CAS Nummer:
[12772-57-5]
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