Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties. Shows strong epileptogenic and convulsant activity. Anticancer compound through inhibition of NF-kappaB and NF-kappaB-regulated gene products. Apoptosis inducer. Suppressed osteoclastogenesis induced by RANKL and tumor cells via the NF-kappaB signaling pathway. Therapeutic option for the management of bone metastatic disease. Synonyms: BRN 0072205, NSC 147755, Coltramyl, 10-thio-Colchicoside, 2-Demethoxy-2-glucosidoxythiocolchicine CAS Number: 602-41-5 Source: Semi-synthetic Molecular Weight: 563.6 Molecular Formula: C27H33NO10S Solubility: Water or ethanol. Appearance: Supplied as a yellow solid. Purity: 95% (NMR) Storage and Stability: Store at 4C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
563.6
Reinheit:
95% (NMR)
Formulierung:
Supplied as a yellow solid.
CAS Nummer:
[602-41-5]
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