PSMB7, Recombinant, Human, aa44-277, His-Tag (Proteasome Subunit beta Type-7, Proteasome Subunit Z, Macropain Chain Z, Multicatalytic Endopeptidase Complex Chain Z)
Artikelnummer:
USB-045455
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| Artikelname: | PSMB7, Recombinant, Human, aa44-277, His-Tag (Proteasome Subunit beta Type-7, Proteasome Subunit Z, Macropain Chain Z, Multicatalytic Endopeptidase Complex Chain Z) |
| Artikelnummer: | USB-045455 |
| Hersteller Artikelnummer: | 045455 |
| Alternativnummer: | USB-045455-10 |
| Hersteller: | US Biological |
| Kategorie: | Molekularbiologie |
| PSMB7, also known as proteasome subunit beta type-7, is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i. Recombinant protein corresponding to aa44-277 from human PSMB7, fused to His-Tag at N-terminal, expressed in E.coli. Accession Number: NP_002790 Molecular Weight: ~27.6kD (255aa) confirmed by MALDI-TOF Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MTTIAGVVYK DGIVLGADTR ATEGMVVADK NCSKIHFISP NIYCCGAGTA ADTDMTTQLI SSNLELHSLS TGRLPRVVTA NRMLKQMLFR YQGYIGAALV LGGVDVTGPH LYSIYPHGST DKLPYVTMGS GSLAAMAVFE DKFRPDMEEE EAKNLVSEAI AAGIFNDLGS GSNIDLCVIS KNKLDFLRPY TVPNKKGTRL GRYRCEKGTT AVLTEKITPL EIEVLEETVQ TMDTS Enzyme Activity: Not determined. This product is recommended for use in applications that do not require a catalytically active form of the protein. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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