ULBP-6, Recombinant, Human, His-Tag, aa26-218
Artikelnummer:
USB-045970
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| Artikelname: | ULBP-6, Recombinant, Human, His-Tag, aa26-218 |
| Artikelnummer: | USB-045970 |
| Hersteller Artikelnummer: | 045970 |
| Alternativnummer: | USB-045970-10,USB-045970-20,USB-045970-50,USB-045970-100,USB-045970-250 |
| Hersteller: | US Biological |
| Kategorie: | Molekularbiologie |
| RAET1L, also known as retinoic acid early transcript 1L, linked to the cell membrane by the GPI anchor. This protein functions as a stress-induced ligand for NKG2D receptor. Its expression is, for example, triggered in course of HCMV infection, but HCMV alters its function. HCMV-encoded UL16 glycoprotein retains RAET1L/ULBP6 inside the cells, preventing it from reaching the cell surface and being exposed to cells of the immune system. It had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands. RAET1L mRNA shows restricted expression in the trachea and some HPV positive cervical carcinoma and colorectal carcinoma cell lines. Recombinant human RAET1L, fused to His-Tag at C-terminal, was expressed in insect cell and purified by using conventional chromatography techniques. Recombinant protein corresponding to aa26-218 from human ULBP-6, fused to His-Tag at C-terminal, expressed in Baculovirus (insect cell). Uniprot/Accession: Q5VY80 Molecular Weight: ~22.9kD (202aa) Biological Activity: Measured by its binding ability in a functional ELISA with Human NKG2D Applications: Suitable for use in SDS-PAGE, Bioactivity. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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