IL-19, Recombinant, Human, His-Tag, aa25-177

Produktübersicht

• Artikelname: IL-19, Recombinant, Human, His-Tag, aa25-177
• Artikelnummer: USB-045971
• Hersteller Artikelnummer: 045971
• Alternativnummer: USB-045971-20,USB-045971-50,USB-045971-100,USB-045971-250
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

IL-19, also known as Interleukin-19, is a member of the IL-10 family of related cytokines, which includes IL-10, IL 19, IL-20, IL-22, IL-24 and IL-26. This protein is an immunosuppressive cytokine that is responsible for both cell type-specific and system-specific down-regulation of inflammation, because it up-regulates IL-6 and TNF-alpha, and induces apoptosis through TNF-alpha. It binds a receptor complex consisting of the IL-20 receptor alpha (IL-20 R1) and the IL-20 receptor beta (IL-20 R2). This receptor complex is also shared by IL-20 and IL-24. IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. It may contribute to the pathogenesis of inflammatory bowel disease. Recombinant human IL-19, fused to His-Tag at C-terminal, was expressed in HEK293 cell and purified by using conventional chromatography techniques. Recombinant protein corresponding to aa25-177 from human IL-19, fused to His-Tag at C-terminal, expressed in HEK293 cells. Accession/Uniprot: Q9UHD0 Molecular Weight: ~19.1kD (164aa) Amino Acid Sequence: LRRCL ISTDMHHIEE SFQEIKRAIQ AKDTFPNVTI LSTLETLQII KPLDVCCVTK NLLAFYVDRV FKDHQEPNPK ILRKISSIAN SFLYMQKTLR QCQEQRQCHC RQEATNATRV IHDNYDQLEV HAAAIKSLGE LDVFLAWINK NHEVMFSA Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 19.1
• NCBI: 037503
• UniProt: Q9UHD0
• Reinheit: 95% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL).
• Formulierung: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.