Thrombospondin 5, Recombinant, Human, His-Tag, aa21-757

Produktübersicht

• Artikelname: Thrombospondin 5, Recombinant, Human, His-Tag, aa21-757
• Artikelnummer: USB-045984
• Hersteller Artikelnummer: 045984
• Alternativnummer: USB-045984-20,USB-045984-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

COMP, also known as Thrombospondin-5, is a member of the thrombospondin(TSP) family. It is an extracellular matrix(ECM) protein primarily present in cartilage and is a secreted glycoprotein that is important for growth plate organization and function. This protein is upregulated in rheumatoid osteoarthritis and arthritis, chronic pancreatitis, hepatocellular carcinomas and pancreatic carcinomas. It is a marker of cartilage turnover. It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling. It also plays a role in cell growth and development. Mutations in COMP can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED), and up regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas. Recombinant human COMP, fused to His-Tag at C-terminal, was expressed in HEK293 cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa21-757 from human Thrombospondin 5, fused to His-Tag at C-terminal, expressed in HEK293. Molecular Weight: ~82.4kD (749aa) Amino Acid Sequence: QGQSPL GSDLGPQMLR ELQETNAALQ DVRELLRQQV REITFLKNTV MECDACGMQQ SVRTGLPSVR PLLHCAPGFC FPGVACIQTE SGARCGPCPA GFTGNGSHCT DVNECNAHPC FPRVRCINTS PGFRCEACPP GYSGPTHQGV GLAFAKANKQ VCTDINECET GQHNCVPNSV CINTRGSFQC GPCQPGFVGD QASGCQRRAQ RFCPDGSPSE CHEHADCVLE RDGSRSCVCA VGWAGNGILC GRDTDLDGFP DEKLRCPERQ CRKDNCVTVP NSGQEDVDRD GIGDACDPDA DGDGVPNEKD NCPLVRNPDQ RNTDEDKWGD ACDNCRSQKN DDQKDTDQDG RGDACDDDID GDRIRNQADN CPRVPNSDQK DSDGDGIGDA CDNCPQKSNP DQADVDHDFV GDACDSDQDQ DGDGHQDSRD NCPTVPNSAQ EDSDHDGQGD ACDDDDDNDG VPDSRDNCRL VPNPGQEDAD RDGVGDVCQD DFDADKVVDK IDVCPENAEV TLTDFRAFQT VVLDPEGDAQ IDPNWVVLNQ GREIVQTMNS DPGLAVGYTA FNGVDFEGTF HVNTVTDDDY AGFIFGYQDS SSFYVVMWKQ MEQTYWQANP FRAVAEPGIQ LKAVKSSTGP GEQLRNALWH TGDTESQVRL LWKDPRNVGW KDKKSYRWFL QHRPQVGYIR VRFYEGPELV ADSNVVLDTT MRGGRLGVFC FSQENIIWAN LRYRCNDTIP EDYETHQLRQ A Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 82.4
• NCBI: 000086
• UniProt: P49747
• Reinheit: 85% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL).
• Formulierung: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.