Podocalyxin, Recombinant, Human, His-Tag, aa23-429

Produktübersicht

• Artikelname: Podocalyxin, Recombinant, Human, His-Tag, aa23-429
• Artikelnummer: USB-046035
• Hersteller Artikelnummer: 046035
• Alternativnummer: USB-046035-20,USB-046035-50,USB-046035-100,USB-046035-250
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Podocalyxin, also known as PODXL, is a member of the CD34 sialomucin protein family. It is present in glomerular podocytes, endothelial cells, glandular cells in fallopian tube, uterus. A soluble form of Podocalyxin can be released into the urine of women with pre-eclampsia. It has been shown to interact with Sodium hydrogen exchange regulatory cofactor 2. And Its interactions with L-Selectin and E-Selectin mediate the tethering of lymphocytes and metastatic tumor cells to the vascular endothelium. It is upregulated in a number of cancers and is frequently associated with poor prognosis. Based on patient survival data, high level of PODXL transcripts in tumor cells is associated with poor prognosis in renal cancer. Recombinant human Podocalyxin, fused to His-Tag at C-terminal, was expressed in HEK293 cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa23-429 from human Podocalyxin, fused His-Tag at C-terminal, expressed in HEK293. Molecular Weight: ~43.1kD (416aa) Amino Acid Sequence: SPSPSPS PSQNATQTTT DSSNKTAPTP ASSVTIMATD TAQQSTVPTS KANEILASVK ATTLGVSSDS PGTTTLAQQV SGPVNTTVAR GGGSGNPTTT IESPKSTKSA DTTTVATSTA TAKPNTTSSQ NGAEDTTNSG GKSSHSVTTD LTSTKAEHLT TPHPTSPLSP RQPTSTHPVA TPTSSGHDHL MKISSSSSTV AIPGYTFTSP GMTTTLPSSV ISQRTQQTSS QMPASSTAPS SQETVQPTSP ATALRTPTLP ETMSSSPTAA STTHRYPKTP SPTVAHESNW AKCEDLETQT QSEKQLVLNL TGNTLCAGGA SDEKLISLIC RAVKATFNPA QDKCGIRLAS VPGSQTVVVK EITIHTKLPA KDVYERLKDK WDELKEAGVS DMKLGDQGPP EEAEDRFSMP Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 43.1
• NCBI: 005388
• UniProt: O00592
• Reinheit: 95% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL).
• Formulierung: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.