TREM2, Recombinant, Human, His-Tag, aa19-174

Produktübersicht

• Artikelname: TREM2, Recombinant, Human, His-Tag, aa19-174
• Artikelnummer: USB-046049
• Hersteller Artikelnummer: 046049
• Alternativnummer: USB-046049-20,USB-046049-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

TREM2, also known as Triggering receptor expressed on myeloid cells 2 isoform 1, is a membrane protein that forms a receptorsignaling complex with the TYRO protein tyrosine kinase binding protein. This protein is found in immune cells termed myeloid cells, which include macrophages, granulocytes, monocytes, and dendritic cells. It functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. It also promotes the differentiation and function of osteoclasts, the production of inflammatory cytokines by adipocytes, insulin resistance, and the phagocytic clearance of bacteria. Defects in TREM2 are acause of polycystic lipomembranous osteodysplasia with sclerosingleukoencephalopathy (PLOSL). In addition, TREM2 is overexpressed in many tumor types and has anti-inflammatory activities. It might therefore be a good therapeutic target. Recombinant human TREM2, fused to His-Tag at C-terminal, was expressed in HEK293 cell and purified by using conventional chromatography techniques. Source: Recombinant protein corresponding to aa19-174 from human TREM2, fused to His-Tag at C-terminal, expressed in HEK293. Molecular Weight: ~18.2kD (162aa) Amino Acid Sequence: HNTTVFQGVA GQSLQVSCPY DSMKHWGRRK AWCRQLGEKG PCQRVVSTHN LWLLSFLRRW NGSTAITDDT LGGTLTITLR NLQPHDAGLY QCQSLHGSEA DTLRKVLVEV LADPLDHRDA GDLWFPGESE SFEDAHVEHS ISRSLLEGEI PFPPTS Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 18.2
• NCBI: 061838
• UniProt: Q9NZC2
• Reinheit: 95% (SDS-PAGE). Endotoxin: 1EU/1ug (LAL).
• Formulierung: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.