Hemoglobin the main component of red blood cells, is a protein that carries oxygen away from the lungs and carbon dioxide back to the lungs. A molecule consists of 2 pairs of peptide (alpha and beta globins) chains and four heme groups, each with one atom of iron. At a normal oxygen tension of 100 mmHg in the blood vessels of the lungs, 95-98% of hemoglobin is combined with oxygen. In the tissues further from the lungs, where the oxygen tension is much lower, the oxygen readily separates from hemoglobin. Higher than normal levels may result in dehydration, excess production of red blood cells in the bone marrow, severe lung disease or other severe conditions. Lower than normal levels may lead to anemia that can result in iron deficiency, B12 and folate deficiency, inherited hemoglobin defect, cirrhosis of the lever, excessive destruction of red bloods cells. CAS Number: 9008-02-0 Source: Human Red Blood Cells Molecular Weight: ~64,400 (Heterotetramer - alpha2beta2) Protein: 0.7mg Hemoglobin/mg solid (Cyanomethemoglobin) Purity: 96% (SDS-PAGE) Form: Lyophilized powder with red-brown powder with buffer salts Solubility: Clear, red-brown solution (1mg/ml H2O) Note: This preparation is predominately methemoglobin Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
64400
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