KLK7 is a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikreins are biomarkers for cancer. The protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. KLK7 may play a role in cancer invasion and metastasis, and increased expression of this protein is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Source: Recombinant protein corresponding to aa30-253 from human KLK7 at N-terminal, fused to His-tag expressed in E.coli. Molecular Weight: ~27.1kD (249aa) Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHM ASKSFRHPGY STQTHVNDLM LVKLNSQARL SSMVKKVRLP SRCEPPGTTC TVSGWGTTTS PDVTFPSDLM CVDVKLISPQ DCTKVYKDLL IIDGA PCARGSHPWQ VALLSGNQLH CGGVLVNERW VLTAAHCKMN EYTVHLGSDT LGDRRAQRIKENSMLCAGIP DSKKNACNGD SGGPLVCRGT LQGLVSWGTF PCGQPNDPGV YTQVCKFTKW INDTMKKHR Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
27.1
Reinheit:
90% (SDS-PAGE)
Formulierung:
Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 2M urea, 10% glycerol.
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