DDB1 (Damage specific DNA binding protein 1, Damage-specific DNA-binding protein 1, DDB 1, DDB p127 subunit, Ddb1, DDB1_HUMAN, DDBa, DNA damage binding protein 1, DNA damage-binding protein 1, DNA damage-binding protein a, HBV X-a
DDB1 (Damage specific DNA binding protein 1, Damage-specific DNA-binding protein 1, DDB 1, DDB p127 subunit, Ddb1, DDB1_HUMAN, DDBa, DNA damage binding protein 1, DNA damage-binding protein 1, DNA damage-binding protein a, HBV X-a
DDB1 (Damage specific DNA binding protein 1, Damage-specific DNA-binding protein 1, DDB 1, DDB p127 subunit, Ddb1, DDB1_HUMAN, DDBa, DNA damage binding protein 1, DNA damage-binding protein 1, DNA damage-binding protein a, HBV X-a
Artikelnummer:
USB-143169
Hersteller Artikelnummer:
143169
Alternativnummer:
USB-143169-100
Hersteller:
US Biological
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
WB
Immunogen:
Purified recombinant human DDB1 protein fragments expressed in E. coli.
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012] Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[13k42]
Isotyp:
IgG2b
Reinheit:
Ascites
Formulierung:
Supplied as a liquid in ascites fluid.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
