JW 67, Wnt pathway Inhibitor (Induces Degradation of Active B-catenin, Trispiro[3H-indole-3,2-[1,3]dioxane-2,3-[3H]indole]-2,2(1H,1H)-dione), CAS [[442644-28-2]]

Produktübersicht

• Artikelname: JW 67, Wnt pathway Inhibitor (Induces Degradation of Active B-catenin, Trispiro[3H-indole-3,2-[1,3]dioxane-2,3-[3H]indole]-2,2(1H,1H)-dione), CAS [[442644-28-2]]
• Artikelnummer: USB-145679
• Hersteller Artikelnummer: 145679
• Alternativnummer: USB-145679-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17um), targets the beta-catenin destruction complex (GSK-3beta/AXIN/APC) to induce beta-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-kappaB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8um). Sequence: C21H18N2O6 Solubility: DMSO (~100mM) Molecular Weight: ~394.38 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 394.38
• Reinheit: ~97% (HPLC)
• Formulierung: Supplied as a solid.
• CAS Nummer: [442644-28-2]