WYE 687 Dihydrochloride (Potent and Selective mTOR Inhibitor, N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyr idinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyr imidin-6-yl]phenyl]-carbamic acid methyl ester hydrochloride), CAS [[1062161-90-3

Produktübersicht

• Artikelname: WYE 687 Dihydrochloride (Potent and Selective mTOR Inhibitor, N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyr idinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyr imidin-6-yl]phenyl]-carbamic acid methyl ester hydrochloride), CAS [[1062161-90-3
• Artikelnummer: USB-145697
• Hersteller Artikelnummer: 145697
• Alternativnummer: USB-145697-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7nm). Displays selectivity for mTOR over PI 3-Kalpha (~100-fold) and PI 3-Kgamma (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt, blocks VEGF secretion and HIF-1alpha expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis. Sequence: C28H32N8O3 Solubility: DMSO (~100mM), H2O (~100mM) Molecular Weight: ~601.53 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 601.53
• Reinheit: ~98% (HPLC)
• Formulierung: Supplied as a pale brown solid.
• CAS Nummer: [1062161-90-3]