BMP4, Recombinant, Human (Bone Morphogenetic Protein 4, BMP-4, Bone Morphogenetic Protein 2B, BMP-2B, BMP2B, DVR4, DVR4, MCOPS6, OFC11, ZYME)
Artikelnummer:
USB-149598
Hersteller Artikelnummer:
149598
Alternativnummer:
USB-149598-1,USB-149598-5
Hersteller:
US Biological
Kategorie:
Molekularbiologie
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36kD homodimeric glycoprotein. Recombinant protein corresponding to human BMP-4, expressed in HeLa cells. Swiss/Uniprot Number: P12644 Amino Acid Sequence: HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP TELSAISMLY LDEYDKVVLK NYQEMVVEGC GCR Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O, 0.1% HSA or BSA. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
