WISP1, Recombinant, Human (WISP-1, WNT1-inducible-signaling Pathway Protein 1, Wnt-1-induced Secreted Protein, CCN Family Member 4, CCN4)
Artikelnummer:
USB-149608
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| Artikelname: | WISP1, Recombinant, Human (WISP-1, WNT1-inducible-signaling Pathway Protein 1, Wnt-1-induced Secreted Protein, CCN Family Member 4, CCN4) |
| Artikelnummer: | USB-149608 |
| Hersteller Artikelnummer: | 149608 |
| Alternativnummer: | USB-149608-5,USB-149608-20 |
| Hersteller: | US Biological |
| Kategorie: | Molekularbiologie |
| WISP-1 is a member of the CCN family of secreted cysteine rich regulatory proteins. It is expressed in the heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. WISP-1 is a beta catenin regulated protein that can contribute to tumorigenesis and has also been shown to play a role in bone development and fracture repair. Human WISP-1 is a 38.1kD protein containing 346aa. It is composed of four distinct structural domains (modules), the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cystine knot-like (CTCK) domain. Recombinant protein corresponding to human WISP-1, expressed in E. coli. Swiss Prot Number: O95388 Biological Activity: The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 1-3ug/ml. Amino Acid Sequence: TALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP WSPCSTSCGL GVSTRISNVN AQCWPEQESR LCNLRPCDVD IHTLIKAGKK CLAVYQPEAS MNFTLAGCIS TRSYQPKYCG VCMDNRCCIP YKSKTIDVSF QCPDGLGFSR QVLWINACFC NLSCRNPNDI FADLESYPDF SEIAN Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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