GW2580 is a small-molecule inhibitor of cFMS kinase, at 60nM it inhibited human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 inhibited lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro. Also, GW2580 at 1uM totally inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes, and prevented bone degradation in cultures of rat calvaria and rat fetal long bone in vitro. Synonyms: (5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine) CAS No: 870483-87-7 Molecular Formula: C20H22N4O3 Molecular Weight: 366.41 Appearance: White to off-white powder Purity: 98% Melting Point: 209-210.5C Elemental Analysis: Calculated: C65.56%, H6.05%, N15.29% Found: C~65%, H~6%, N~15% Solubility: Soluble in DMSO at 40mg/ml, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 20-100uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
366.41
Reinheit:
98%
Formulierung:
White to off-white powder
CAS Nummer:
[870483-87-7]
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