Used in the systematic treatment of advanced cutaneous melanoma. An EGFR kinase inhibitor and potent MEK inhibitor. Synonyms: G 02442104, GSK 1120212, JTP 74057, N-[3-[3-Cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethy-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide CAS No: 871700-17-3 Molecular Formula: C26H23FIN5O4 Molecular Weight: 615.39 Purity: 99% (HPLC/TLC) Appearance: White to off-white to beige powder Melting Point: 299-301C (lit) Solubility: Soluble in DMSO at 20mg/ml with warming, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-10uM, buffers, serum or other additives may increase or decrease the aqueous solubility. Elemental Analysis: Calculated: %C: 49.73% %H: 3.92% %F: 3.03% %I: 20.21% %N: 11.15% Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
615.39
CAS Nummer:
[871700-17-3]
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