| Sodium salt of Suramin, a hepatitis C virus NS3 helicase inhibitor. Also used in the treatment of arthritis due to problematic collagen. A P2x and P2y purinergic receptor antagonist that displays antitumor, antiangiogenic and antiparasitic activities. Inhibits sirtuin 1, sirtuin 5 and topoisomerase II. Inhibits the cell surface binding of various growth factors including PDGF, EGF, FGFa and FGFb. Blocks association of G protein alpha and b/g-subunits. Potent competitive inhibitor of reverse transcriptase and protects T lymphocytes against in vitro human immunodeficiency virus infection. Potent ATPase inhibitor. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity. Anticancer compound. Protein kinase C (PKC) inhibitor. Potent inhibitor of melanoma heparanase and tumor cell metastasis. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF). TGF-beta1 inhibitor. Topoisomerase I and II inhibitor. Interleukin-1 (IL-1) inhibitor. Interleukin-4 (IL-4) inhibitor. G protein inhibitor. P2X and P2Y purinergic receptor antagonist. Antiangiogenic. Potent VEGF inhibitor. Telomerase inhibitor. Shows adjuvant properties. Regulates ryanodine receptor. Direct adenylyl cyclase inhibitor. Protein synthesis inhibitor. SIRT1 (Sirtuin 1) and SIRT5 (Sirtuin 5) inhibitor. Immunosuppressive. Antifibrotic agent. Antiparasitic. Antiprotozoal. Athelmintic. Synonyms: 8,8-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic Acid Sodium Salt (1:6), 8,8-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt, 8,8-[Ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt, 309F, 8,8-[Ureylenebis[m-phenylene carbonylimino(4-methyl-m-phenylene)carbonylimino]]di(1,3,5-naphthalenetrisulfonic Acid) Hexasodium Salt, Antrypol, BAY 205, Bayer 205, CI 1003, Fourneau 309, Germanin, Germanin (pharmaceutical), Hexasodium Sym.-bis(m-aminobenzoyl)-m-amino-p-methylbenzoyl-1-naphthylamino-4,6,8-trisulfonate) Carbamide, Moranyl, NF 060, Naganin, Naganine, Naphuride, Naphuride sodium, Sodium Suramin, Suramin Hexasodium, Suramin Sodium, Suramine Sodium CAS No: 129-46-4 Molecular Formula: C51H34N6Na6O23S6 Molecular Weight: 1429.17 Appearance: White to off-white solid Purity: 98% (HPLC) 1H-NMR: Conforms to reference Melting Point: >260C (dec.) Water (KF): 15% Sodium: 8-9% Solubility: DMSO (10mM), Water (50mM), Methanol (Slightly) Storage and Stability: Short-term Storage: +4C Long-term Storage: +4C Stable for at least 2 years after receipt when stored at +4C. |
