KIR2DL1 (Killer Cell Immunoglobulin-like Receptor, Two Domain Long Cytoplasmic Tail, 1, CD158A) (PerCP), IgG1, Clone: [143211], Mouse, Monoclonal
Artikelnummer:
USB-167671
Hersteller Artikelnummer:
167671
Alternativnummer:
USB-167671-25,USB-167671-100
Hersteller:
US Biological
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FC
Immunogen:
BaF3 mouse pro-B cell line transfected with human KIR2DL1/KIR2DS5
Killer Immunoglobulin-like Receptors (KIRs) play a major role in regulating the cytotoxic function of natural killer (NK) cells and CD8+ memory T cells. The KIR family displays extreme haplotypic polymorphism, differing in the number and type of KIR genes expressed. In addition, the KIR genes demonstrate considerable allelic polymorphism. NK cell development dictates clonal expression of KIRs that leads to numerous NK cell subsets expressing different KIR proteins. The names of the KIR proteins are derived from their structure. The extracellular segments contain either two or three Ig- like domains (2D or 3D). The cytoplasmic domains of the KIR proteins are either short (S) implying an activating signal, or long (L) usually implying an inhibitory signal. Signaling through the KIR receptors occurs upon binding their natural class I HLA ligands. KIR2DL1 is specific for HLA-C with Asn77 and Lys80 alleles. Of clinical relevance, the KIR2D short and long receptors play a role in psoriatic arthritis. In addition, increased percentages of KIR2DL1+ NK cells have been correlated with an increased risk for endometriosis. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 10ul, 10e6 cells Optimal dilutions to be determined by the researcher. Hybridoma: Myeloma cells with spleen cells from Balb/c mice. Absorption: 482-564nm Emission: 675nm Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. PerCP conjugates are sensitive to light.
