Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39ug/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10-20uM. References Synonyms: (E)-5-(sec-Butyl)-3-((2-(2,3-dimethyloxiran-2-yl)-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)(hydroxy)methylene)-1-methylpyrrolidine-2,4-dione CAS Number: 147317-15-5 Source: Phoma sp. Molecular Formula: C26H39NO4 Molecular Weight: 429.6 Appearance: Light brown solid Purity: 98% (HPLC) Method for Determining Identity: Proton NMR Solubility: DMSO, Methanol, Methylene Chloride, Chloroform (all at 10mg/ml) Storage and Stability: Lyophilized and reconstituted products are are stable for 6 months after receipt. Store at -20C. Light sensitive Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Molekulargewicht:
429.6
Reinheit:
98% (HPLC)
Formulierung:
Light brown solid
CAS Nummer:
[147317-15-5]
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