| Antibiotic against Gram-positive bacteria, particularly Staphylococcus and Clostridia. More effective against multi-resistant strains (MRSA) than erythromycin and vancomycin. Inhibits cell proliferation and induces HL-60 cell differentiation in combination with 1,25-Dihydroxyvitamin-D3 and ATRA. Displays low cytotoxicity compared to erythromycin and spiramycin. Alternate Names: Antibiotic 47444, CP 47444, NSC 355066, Nargenicin, Nargenicin A1, Stereoisomer of 3,4,6,7,8,8a,10a,11,12,13,14,14a-dodecahydro-14-hydroxy-4-(1-hydroxyethyl)-7-methoxy-1,3,13-trimethyl-6-oxo-11,14b-epoxy-14bH-naphth[2,1-e]oxecin-12-yl 1H-pyrrole-2-carboxylate, [3R-[1E,3R*,4S*(R*),7S*,8aS*,10aR*,11R*,12R*,13R*,14R*,14aS*,14bS*]]-1H-Pyrrole-2-carboxylic acid 3,4,6,7,8,8a,10a,11,12,13,14,14a-Decahydro-14-hydroxy-4-(1-hydroxyethyl)-7-methoxy-1,3,13-trimethyl-6-oxo-11,14b-epoxy-14bH-naphth[2,1-e]oxecin-12-yl Ester, 9-(1H-Pyrrole-2-carboxylate) Nodusmicin CAS Number: 70695-02-2 Source: Actinomyces sp. Gö301 Molecular Formula: C28H37NO8 Solubility: DMSO or methanol Molecular Weight: 515.6 Method for Determining Identity: Proton NMR Purity: 98% (HPLC) Appearance: Off-white powder Storage and Stability: May be stored at 4C for short-term only. Long-term storage is recommended at -20C. Stable for 1 year after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
