CRTC2 (CREB regulated transcription coactivator 2, TORC2, CREB-regulated transcription coactivator 2, TORC-2, Transducer of CREB protein 2, Transducer of regulated cAMP response element-binding protein (CREB) 2, Transducer of regu
Artikelnummer:
USB-208095
Hersteller Artikelnummer:
208095
Alternativnummer:
USB-208095-100
Hersteller:
US Biological
Wirt:
Goat
Kategorie:
Antikörper
Applikation:
ELISA, WB
Immunogen:
Synthetic peptide corresponding to C-HGQQPYHRPIND, from the internal region of mouse CRTC2
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Hormonal and energy-sensing pathways converge on the coactivator TORC2 (transducer of regulated CREB activity 2) to modulate glucose output. Sequestered in the cytoplasm under feeding conditions, TORC2 is dephosphorylated and transported to the nucleus where it enhances CREB-dependent transcription in response to fasting stimuli. Conversely, signals that activate AMPK attenuate the gluconeogenic programme by promoting TORC2 phosphorylation and blocking its nuclear accumulation. Applications: Suitable for use in Peptide ELISA and Western Blot. Other applications not tested. Recommended Dilution: Peptide ELISA: 1:32,000 Western Blot: 0.03-0.1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
