Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene. The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system, it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic Factor. NT-3 binds three receptors on the surface of cells which are capable of responding to this growth factor: TrkC (pronounced Track C), is apparently the physiologic receptor, in that it binds with greatest affinity to NT-3. However, NT-3 is capable of binding and signaling through a TrkC-related receptors called TrkB. Finally, NT-3 also binds a second-receptor type besides Trk receptors, called the LNGFR (for low affinity nerve growth factor receptor). Human and mouse NTF-3 are identical and high degree of sequence conservation on rat, pig, dog, chicken, hamster etc. Source: Recombinant protein corresponding to 240aa from human Neurotrophin-3, expressed in E. coli. Molecular Weight: ~13.6kD, NTF-3 is a homodimer of two 13.6kD monomers of 240aa Biological Activity: The ED50 was measured by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures. It was found to be in the range of 25-50ng/ml. Endotoxin: <0.1ng/ug protein or <1EU/ug protein Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molekulargewicht:
13.6
Reinheit:
Highly Purified (~95%)
Formulierung:
Supplied as a liquid in PBS, pH 7.4.
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