Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections. Synonyms: PF562271, N-[3-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-methanesulfonamide Hydrochloride CAS Number: 717907-75-0 Molecular Weight: 507.5 Molecular Formula: C21H20F3N7O3S Target: FGFR Kinase Group: RTK Substrate: Tyrosine Appearance: Supplied as a solid. Purity: 95% Solubility: DMSO or ethanol Storage and Stability: Store short term at 4C. Stable for 12 months after receipt when stored at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
507.5
Reinheit:
95%
Formulierung:
Supplied as a solid.
CAS Nummer:
[717907-75-0]
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