CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10, Mig and I-TAC. The protein is mainly expressed on activated Th1 cells, B cells and natural killer cells. It is activated by the interferon-gamma-inducible chemokines CXCL9, CXCL10 and CXCL11, with CXCL11 having the highest affinity. Upon activation, CXCR3 activates pertussis toxin-sensitive G proteins of the Galphai class and mediates, among others, chemotaxis, calcium flux and activation of kinases such as p44/p42 MAPK and Akt. The protein and its ligands are upregulated in a wide variety of inflammatory diseases, implying a role for CXCR3 in serious disorders (e.g. rheumatoid arthritis, multiple sclerosis, transplant rejection, atherosclerosis and inflammatory skin diseases) and thus has attracted considerable attention as a drug target. The gene encoding for human CXCR3 is localized in the chromosomal region Xq13. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50-200 Immunohistochemistry: 1:20-100 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[14L328]
Isotyp:
IgG1
Reinheit:
Purified by Protein G affinity chromatography from culture supernatant.
Formulierung:
Supplied as a lyophilized powder in PBS. Reconstitute with 200ul sterile PBS.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
