Akt Inhibitor XIX, 3CAI (2-Chloro-1-(1H-indol-3-yl)-ethanone, 3-Chloroacetyl-indole), CAS [[28755-03-5]]

Produktübersicht

• Artikelname: Akt Inhibitor XIX, 3CAI (2-Chloro-1-(1H-indol-3-yl)-ethanone, 3-Chloroacetyl-indole), CAS [[28755-03-5]]
• Artikelnummer: USB-217170
• Hersteller Artikelnummer: 217170
• Alternativnummer: USB-217170-25
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1uM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively, 4uM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50=30mg/kg, 5 times/wk for 3 wks via p.o.) in vivo. CAS Number: 28755-03-5 Formula: C10H8ClNO Molecular Weight: 193.6 Solubility: DMSO (100mg/ml) Purity: 98% (HPLC) Appearance: Supplied as a pink solid. Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Produkteigenschaften

• Molekulargewicht: 193.6
• Reinheit: 98% (HPLC)
• Formulierung: Supplied as a pink solid.
• CAS Nummer: [28755-03-5]