AMPK Signaling Activator XIII, ZLN005 (2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV), CAS [[4529-96-8]]

Produktübersicht

• Artikelname: AMPK Signaling Activator XIII, ZLN005 (2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV), CAS [[4529-96-8]]
• Artikelnummer: USB-217177
• Hersteller Artikelnummer: 217177
• Alternativnummer: USB-217177-25
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable benzimidazole that, in addition to its inhibitory potency against luciferase activity (IC50 <10nM), also activates AMPK signaling by increasing cellular ADP/ATP ratio via mitochondria respiration upcoupling, effectively activating AMPK & PGC-1alpha in muscle, but not liver, cell types both in cultures (5-20uM in rat L6 myotubes) in vitro and in db/db mice (15mg/kg/day via p.o.) in vivo. Reported to improve glucose and insulin tolerance of db/db mice without any apparent effects on body weight or food intake. Synonyms: 2-(4-tert-Butylphenyl)-1H-benzo[d]imidazole, 2-(4-(2-Methyl-2-propanyl)phenyl)-1H-benzimidazole, Luciferase Inhibitor IV CAS Number: 4529-96-8 Molecular Formula: C17H18N2 Solubility: DMSO Primary Target: Increases cellular ADP/ATP ratio via mitochondria respiration uncoupling Secondary Target: Luciferase activity inhibitor Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Reinheit: 99% (HPLC)
• Formulierung: Supplied as a pinkish-white powder.
• CAS Nummer: [4529-96-8]