A potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.33, 0.80, and 0.38uM for GluK1, GluK1/K2, and GluK1/K5, respectively) over GluK2-containing subtypes (EC50 = 106 and °uM for GluK2/K5 and GluK2 respectively). Weakly interacts with AMPA receptors (EC50 = 7.6, 7.9 and 22uM for GluA4, GluA3, and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in synaptic transmission and plasticity. Synonyms: 2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, (RS)-2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, Kainate Receptor Agonist, ATPA, (R,S)-ATPA Molecular Formula: C10H16N2O4 Solubility: Aqueous basic solutions Primary Target: GluK1 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Reinheit:
97% (TLC)
Formulierung:
Supplied as a white powder.
CAS Nummer:
[140158-50-5]
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