Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor III, PF-8380, 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one), CAS [[1144035-53-9]]

Produktübersicht

• Artikelname: Autotaxin Inhibitor III, PF-8380 (Atx Inhibitor III, PF-8380, 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one), CAS [[1144035-53-9]]
• Artikelnummer: USB-217206
• Hersteller Artikelnummer: 217206
• Alternativnummer: USB-217206-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC50=2.8 and 1.7nM for recombinant human enzyme-b isoform employing FS-3 and LPC (lysophosphatidylcholine) as substrates, respectively, 1.16 and 1.15nM for rat/murine enzyme-FS-3 and fetal fibroblast cell-LPC, 101nM for human whole blood}. Displays desirable pharmacokinetics properties and efficiently blocks inflammation-induced LPA (lysophosphatidic acid) production both in plasma and at the site of inflammation by 95% in rat adjuvant-induced arthritis model (30mg/kg, p.o.). Synonyms: 6-(3-(Piperazin-1-yl)propanoyl)-benzo[d]oxazol-2(3H)-one, Atx Inhibitor III, PF-8380 CAS No: 1144035-53-9 Molecular Formula: C22H21Cl2N3O5 Solubility: DMSO Molecular Weight: 478.3 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 478.3
• Reinheit: 95% (HPLC)
• Formulierung: Supplied as a tan powder.
• CAS Nummer: [1144035-53-9]