Beclin-1 Activator II, Retro-inverso TAT-Beclin-1 ((D)-H2N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO2H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II)

Produktübersicht

• Artikelname: Beclin-1 Activator II, Retro-inverso TAT-Beclin-1 ((D)-H2N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO2H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II)
• Artikelnummer: USB-217214
• Hersteller Artikelnummer: 217214
• Alternativnummer: USB-217214-5
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable, all-D-amino acid autophagy-inducing peptide based on the retro-inverso sequence of Tat-Beclin1 that is expected to be more resistant to proteolytic degradation than Tat-Beclin1 and is shown to be more potent than Tat-Beclin1 in inducing autophagy in muscle, heart, and pancreas tissues in 6-wk-old GFP-LC3 transgenic mice (20mg/kg i.p.) in vivo. Only the retro-inverso peptide, but not Tat-Beclin1, is effective in reducing autophagy substrate p26 level in the brain tissue of 5-d-old neontal GFP-LC3 mice (20mg/kg i.p.). The retro-inverso peptide treatment is also reported to greatly reduce brain viral titre in neonatal mice subjected to West Nile Virus infection. Sequence: (D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH Molecular Formula: C164H251N57O45 Solubility: DMSO or H2O Primary Target: GAPR-1/GLIP Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Reinheit: ~95% (HPLC)
• Formulierung: Supplied as a white powder.