A cell-permeable pyrazinopyrimidinecarboxamide that competes against beta-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/beta-catenin transcriptional regulations both in cultures in vitro (5 to 25uM) and in mice in vivo (5mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE complex. Shown to reactivate p300//TCF/beta-catenin-mediated neuronal differentiation upon NGF stimulation in PS-1 L286V mutant-expressing PC-12 cultures and be efficacious in alleviating bleomycin- (0,08 units/50 uL/mouse, administered intranasally) induced pulmonary fibrosis in mice. Synonyms: (6S,9aS)-Hexahydro-6-((4-hydroxyphenyl)methyl)-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide, (6S)-N-Benzyl-6-(p-hydroxyphenylmethyl)-8-(1-naphthylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ICG001, Wnt Pathway Inhibitor XX CAS No: 847591-62-2 Molecular Formula: C33H32N4O4 Solubility: DMSO Primary Target: CREB-binding protein Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Reinheit:
~99% (HPLC)
Formulierung:
Supplied as an off-white powder.
CAS Nummer:
[847591-62-2]
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