CARM1 Inhibitor (1-Benzyl-3,5-bis-(3-bromo-4-hydroxybenzylidene)piperidin-4-one, 3,5-bis(3-Bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one, Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, PRMT Inhibitor V)10

Produktübersicht

• Artikelname: CARM1 Inhibitor (1-Benzyl-3,5-bis-(3-bromo-4-hydroxybenzylidene)piperidin-4-one, 3,5-bis(3-Bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one, Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, PRMT Inhibitor V)10
• Artikelnummer: USB-217249
• Hersteller Artikelnummer: 217249
• Alternativnummer: USB-217249-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable (bis-benzylidene)piperidinone compound that acts as a selective inhibitor against CARM1/PRMT4 arginine methyltransferase activity (IC50=7.1uM with PABP1 as substrate). It inhibits PRMT3 only at much higher concentrations (by 70% and 62% with 100uM inhibitor using NPL3 or rpS2 as substrate, respectively), exhibiting little activity against PRMT1, PRMT5, PRMT6 (IC50>100uM), or four HKMTs (<20% inhibition against DOTL1, G9a, SET7, or Suv39H1 with 100uM inhibitor). Shown to inhibit PSA promoter-mediated reporter transcription in LNCaP cells in a dose-dependent manner (by 74% and 97%, respectively, with 4 and 6uM inhibitor). Formula: C26H21Br2NO3 Primary Target: PRMT4 Primary Target IC50: CARM1-mediated methylation over PRMT1 and SET7 (IC50 = 7.1, 63 and 943uM Secondary target: SET7 Molecular Weight: 555.3 Solubility: DMSO Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 555.3
• Reinheit: ~95% (HPLC)
• Formulierung: Supplied as a orange solid.