CXCR4 Antagonist IV, TF14016 (Fusin Antagonist IV)

Produktübersicht

• Artikelname: CXCR4 Antagonist IV, TF14016 (Fusin Antagonist IV)
• Artikelnummer: USB-217301
• Hersteller Artikelnummer: 217301
• Alternativnummer: USB-217301-2
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1alpha/CXCL12 for CXCR4 binding (IC50 = 0.91nM, [SDF-1] = 100nM) and protects MT-4 cells against X4-HIV strain HIV-1IIIB infection (EC50 = 4nM in 5 d, MOI = 0.01) with no significant cytotoxicity (CC50 = 56uM, 5 d). Inhibits SDF-1-induced Ca2+ mobilization (IC50 = 4.5nM, [SDF-1] = 30nM, CXCR4-expressing CHO cells) in vitro and effectively prevents CXCR4-dependent 5BC-5 metastasis in NK-depleted SCID mice in vivo (10mg/kg i.p.) in vivo. Molecular Formula: C101H145FN34O18S2.xH2O Sequence: N alpha-4-fluorobenzoyl-Arg-Arg-Nal-Cys4-Tyr-Cit-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys3-Arg-NH2 (Disulfide bond: 4 13, Nal = L-3-(2-naphthyl)alanine, Cit = L-citrulline) Solubility: H2O Primary Target: CXCR4 Primary Target IC50: 0.9nM Molar Mass: 2206.58 Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Produkteigenschaften

• Molekulargewicht: 2206.58
• Reinheit: 95% (HPLC)
• Formulierung: Supplied as a white solid.