Cytoplasmic Dynein Inhibitor, Ciliobrevin D (2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile)(AAA+ ATPase Motor Cytoplasmic Dynein Inhibitor), CAS [[1370554-01-0]]

Produktübersicht

• Artikelname: Cytoplasmic Dynein Inhibitor, Ciliobrevin D (2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile)(AAA+ ATPase Motor Cytoplasmic Dynein Inhibitor), CAS [[1370554-01-0]]
• Artikelnummer: USB-217307
• Hersteller Artikelnummer: 217307
• Alternativnummer: USB-217307-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable benzoyl dihydroquinazolinone derivative that acts as a reversible and specific blocker of AAA+ ATPase motor cytoplasmic dynein and disrupts spindle pole focusing, cold-stable microtubule formation, kinetochore-microtubule attachment, and melanosome aggregation in a dose-dependent manner (~10-40uM). Shown to perturb protein trafficking within the primary cilia and cause a significant increase in intraflagellar transport protein 88 (IFT88) levels at the distal tip of primary cilia. Reported to disrupt primary cilium-dependent Gli regulation and block Hedgehog signaling. Synonyms: 2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile, AAA+ ATPase motor cytoplasmic dynein inhibitor CAS No: 1370554-01-0 Molecular Formula: C17H8Cl3N3O2 Molecular Weight: 392.6 Solubility: DMSO (2.5mg/ml) Form: Supplied as an orange powder. Purity: 99% (HPLC) Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Produkteigenschaften

• Molekulargewicht: 392.6
• CAS Nummer: [1370554-01-0]