AS057278 (5-Methyl-1H-pyrazole-3-carboxylic acid), CAS [[402-61-9]]

Produktübersicht

• Artikelname: AS057278 (5-Methyl-1H-pyrazole-3-carboxylic acid), CAS [[402-61-9]]
• Artikelnummer: USB-217308
• Hersteller Artikelnummer: 217308
• Alternativnummer: USB-217308-250,USB-217308-1,USB-217308-5
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable pyrazolocarboxylic acid that acts as a selective D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) inhibitor (IC50 = 910nM against human DAO, [D-ser] = 10mM) and effectively protects DAO overexpressing cultures from oxidative stress-induced cell death upon D-Ser (50mM) exposure (ED50 3.95uM), while exhibiting little affinity toward nMDAR glycine binding site or inhibitory activity against D-aspartate oxidase (DDO/DSOX). Reported to be orally available and blood-brain barrier-permeant in rats and effectively prevent PCP (phencyclidine) from suppressing PPI (prepulse inhibition) response in mice (single 80mg/kg or 56X 20mg/kg/12h b.i.d. oral dosages) in vivo. CAS No: 402-61-9 Molecular Formula: C5H6N2O2 Molar Mass: 126.11 Solubility: DMSO Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 126.11
• Reinheit: 97%
• Formulierung: Supplied as a white solid.
• CAS Nummer: [402-61-9]