Daminozide (JHDM Inhibitor VI, N,N-Dimethylamino-succinamic Acid, Succinic Acid-2,2-dimethylhydrazide, 4-(2,2-Dimethylhydrazinyl)-4-oxobutanoic Acid, BHC100 Inhibitor VI, KDM2A Inhibitor, KIAA1718 Inhibitor VI, LSD Inhibitor VI, P

Produktübersicht

• Artikelname: Daminozide (JHDM Inhibitor VI, N,N-Dimethylamino-succinamic Acid, Succinic Acid-2,2-dimethylhydrazide, 4-(2,2-Dimethylhydrazinyl)-4-oxobutanoic Acid, BHC100 Inhibitor VI, KDM2A Inhibitor, KIAA1718 Inhibitor VI, LSD Inhibitor VI, P
• Artikelnummer: USB-217311
• Hersteller Artikelnummer: 217311
• Alternativnummer: USB-217311-1
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A dimethylamino substituted succinamate that, in addition to its well known use as a plant growth regulator, also acts as an inhibitor against histone lysine demthylases KDM2A, LSD1 (KDM7A, KIAA1718), and PHF8 (IC50 = 1.5, 2.1, and 0.55uM, respectively), but not KDM3A, KDM4E, KDM5C, KDM6B, or three hydroxylases (IC50 >100uM). Substrate-competition and/or active site Iron chelating likely accounts for the inhibitory activity against the FAD-dependent LSD1, while 2-oxoglutarate (2-OG) competition (Ki = 1.97uM) appears as the major mode of action against KDM2A. CAS Number: 1596-84-5 Formula: C6H12N2O3 Solubility: H2O Molar Mass: 160.2 Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 160.2
• Reinheit: 98% (NMR)
• Formulierung: Supplied as a white powder.
• CAS Nummer: [1596-84-5]