DNA Methyltransferase Inhibitor V, RSC133 (DNA MTase Inhibitor V, (E)-3-(3-(1H-Indol-3-yl)acrylamido)benzamide, ID133, iPSC Induction Enhancer III, Reprogramming Stimulating Compound 133)

Produktübersicht

• Artikelname: DNA Methyltransferase Inhibitor V, RSC133 (DNA MTase Inhibitor V, (E)-3-(3-(1H-Indol-3-yl)acrylamido)benzamide, ID133, iPSC Induction Enhancer III, Reprogramming Stimulating Compound 133)
• Artikelnummer: USB-217317
• Hersteller Artikelnummer: 217317
• Alternativnummer: USB-217317-25
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable indolylacrylamido-benzamide compound that is reported to target Dnmt1 at the cofactor SAM-binding site and enhance the efficiency of iPSC production from both murine MEF (10uM starting 5 d post KSOM viral infection) and human foreskin fibroblast (10uM starting same day as or 5 d post KSOM viral infection) cultures with accompanying cellular Dnmt1 activity reduction, affecting hFF viability only at high concentrations (78% of control post 72h 100uM treatment). Also shown to help maintain H9 hESCs in undifferentiated state when cultured in unconditioned media (10uM). Synonyms: (E)-3-(3-(1H-Indol-3-yl)acrylamido)benzamide, ID133, iPSC Induction Enhancer III, Reprogramming Stimulating Compound 133, DNA MTase Inhibitor V Molecular Formula: C18H15N3O2 Primary Target: Dnmt1 Solubility: DMSO Storage and Stability: Store at 4C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Produkteigenschaften

• Reinheit: 98% (HPLC)
• Formulierung: Supplied as a light yellow powder.