A cell-permeable 3,4-diaminoethylbenzoate-based antioxidant that effectively prevents Glutamate- (5mM, 3h) induced neurotoxicity in cultured rat OHSC (by 56%, 65%, and 71%, respectively, in CA1, CA3, and Dentrate gyrus, [Fer-1] = 2uM, added 0.5h prior to Glutamate) and Erastin- (50uM, 24h) induced HT-1080 death (EC50 = 60nM) by blocking cytosolic and lipid ROS accumulation (by >80% at 0.5uM in 10uM Erastin-treated HT-1080 cells). Fer-1 does not prevent H2O2- induced necrosis, STS-induced apoptosis, or Iron-independent oxidative death by Rotenone. Solubility: DMSO Primary Target: Free radical scavenger Molar Mass: 262.4 Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
262.4
Reinheit:
~99% (HPLC)
Formulierung:
Supplied as a tan solid.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
