g-Secretase Inhibitor XX ((S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine), CAS [[209984-56-5]]

Produktübersicht

• Artikelname: g-Secretase Inhibitor XX ((S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine), CAS [[209984-56-5]]
• Artikelnummer: USB-217372
• Hersteller Artikelnummer: 217372
• Alternativnummer: USB-217372-500,USB-217372-1
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A cell-permeable dibenzazepine (dbz) compound that acts as a potent y-secretase inhibitor and significantly lowers both brain and plasma AB40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100umol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50=1.7nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10umol/kg, i.p). CAS Number: 209984-56-5 Synonyms: (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine Formula: C26H23F2N3O3 Primary Target: g-secretase Secondary Target: Notch processing (IC50 = 1.7nM in SupT1 cells) Solubility: DMSO Molecular Weight: 463.4 Storage and Stability: Store at -20C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Produkteigenschaften

• Molekulargewicht: 463.4
• Reinheit: 95% (HPLC)
• Formulierung: Supplied as a white solid. Packaged under inert gas.
• CAS Nummer: [209984-56-5]