Ghrelin Receptor Antagonist, JMV 2959, CAS [[925238-89-7]]

Produktübersicht

• Artikelname: Ghrelin Receptor Antagonist, JMV 2959, CAS [[925238-89-7]]
• Artikelnummer: USB-217382
• Hersteller Artikelnummer: 217382
• Alternativnummer: USB-217382-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

A 1, 2, 4-triazole derived compound that acts as a potent ghrelin receptor (GHS-R1a) antagonist (IC50 = 32nM in a binding assay, dissociation constant Kb = 19nM). Shown to reduce hexarelin-induced food intake [hexarelin (80ug/kg, cumulative food intake (g of food/100g of body weight) at 6h by acute administration (sc) of JMV 2959 (160ug/kg)] in rats without affecting the basal food intake. Also suppresses ghrelin and fasting-induced food intake at the level of the central nervous system. Reported to suppress genes up-regulated by ghrelin. Does not affect intracellular Ca2+ mobilization. Synonyms: (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide Hydrochloride, GHSR1a Antagonist, GH Secretagogue Receptor Antagonist, JMV2959, Growth Hormone Secretagogue Receptor Antagonist CAS Number: 925238-89-7 Molecular Formula: C14H14N4O Molecular Weight: 254.29 Appearance: Supplied as a beige powder. Purity: ~98% (HPLC) Primary Target: Ghrelin receptor Primary Target IC50: 32nM Storage and Stability: May be stored at 4C. For long-term storage, aliquot and store at 4C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 254.29
• Reinheit: 98% (HPLC)
• Formulierung: Supplied as a beige powder.
• CAS Nummer: [925238-89-7]